Jun 03, 2020 · Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation. Shuaijiang Jin 1, Roberto J. Brea 1, Andrew K. Rudd 1, Stuart P. Moon 2,
Jun 03, 2020 A “Traceless” Staudinger Ligation for the Chemoselective Traceless Ligation of Cysteine Peptides Using Selective Deselenization. Angewandte Chemie International Edition 2010, 49 (39) , 7049-7053. DOI: 10.1002/anie.201001900. Norman Metanis, Ehud Keinan, Philip E. Dawson. Traceless Ligation of Cysteine Peptides Using Selective Deselenization. Convergent Glycopeptide Synthesis by Traceless Staudinger An approach combining traceless Staudinger ligation and protease‐catalyzed N‐terminal azidonation has been shown to be efficient for the convergent synthesis of glycopeptides without the cysteine limitation of native chemical ligation.
Peptide ligation is an indispensable step in the chemical synthesis of target peptides and proteins that are difficult to synthesize at once by a solid-phase synthesis. The ligation reaction is generally conducted with two peptide fragments at a high aqueous concentration to increase the reaction ra …
Herein, we report a traceless ligation at Val-Xaa sites under mild thiol additive-free reaction conditions, whereby the introduction of β-mercaptan on the C-terminal valine residue effectively activates the otherwise unreactive N-acyl-benzimidazolinone (Nbz), and enables the use of a one-pot ligation–desulfurization strategy to generate the ChemInform Abstract: Traceless Chemical Ligation from S ChemInform Abstract: Traceless Chemical Ligation from S-, O-, and N-Acyl Isopeptides Article in Accounts of Chemical Research 47(4) · March 2014 with 133 Reads How we measure 'reads' Traceless chemical ligation from S -, O -, and N-acyl
May 24, 2017
Convergent Glycopeptide Synthesis by Traceless Staudinger An approach combining traceless Staudinger ligation and protease‐catalyzed N‐terminal azidonation has been shown to be efficient for the convergent synthesis of glycopeptides without the cysteine limitation of native chemical ligation. Traceless Chemical Ligation from S-, O-, and N-Acyl